Cancer in familial hemophagocytic lymphohistiocytosis


Hemophagocytic lymphohistiocytosis: a rare complication of autologous stem cell transplant Hemophagocytic lymphohistiocytosis: a rare complication of autologous stem cell transplantation.

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Rom J Morphol Embryol ; 57 2 : HLH is usually fatal without treatment so that accurate and timely diagnosis is very important. The syndrome occurs as a familial disorder familial HLH - FLH or as an acquired condition secondary - sHLH in association with a variety of pathologic states: infectionsrheumatologic, malignant or metabolic diseases.

cancer in familial hemophagocytic lymphohistiocytosis

Malignancy associated HLH is primarily reported in T÷NK natural killer - cell malignancies but also in B-cell neoplasms and other types of cancer. HLH has also been reported in rare cases as a highly fatal and difficult to diagnose complication of stem cell transplantation SCT.

In this paperwe present the case of a young male patient who underwent autologous SCT as consolidation therapy for a T÷NK- cell lymphomacomplicated with graft failure due to HLH.

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The patient was successfully treated with corticosteroidsEtoposideCyclosporine and immunoglobulins. As a particularity, he developed a second B-cell neoplasia a few months after SCT.

cancer in familial hemophagocytic lymphohistiocytosis