T humaan papillomavirus. Infecţia cu virusul papiloma uman şi strategii de implementare a imunizării


Vegetațiile veneriene, negii venerieni sau genitali, condiloamele sau verucile genitale, toate aceste denumiri sunt sinonime ale infecției cu virusul HPV. Cu peste de tulpini descoperite în momentul actual, afecțiunile acestui virus pot fi simptomatice sau nu. Cea mai frecventă manifestare a virusului HPV este reprezentată de negii apăruți în diferite zone ale corpului, cum ar fi la nivelul mâinilor, picioarelor sau în zona genitală.

Department of Ophthalmology, Grigore T. E-mail: moc.

We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.

The method used for the detection of HPV was real time polymerase chain reaction. The evolution t humaan papillomavirus favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence.

papilom pe forța feței

Keywords: Conjunctiva, eye, human papillomavirus t humaan papillomavirus, real time polymerase chain reaction, squamous cell carcinoma Human t humaan papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells. Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half.

t humaan papillomavirus

He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.

The patient admits being a heavy smoker for almost 30 years and that in his free pancreatic cancer erlotinib he practices agriculture without using sunglasses.

All other ophthalmological findings were normal.

îndepărtarea papiloma de pe pleoapă

Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes.

tenă cu panglică largă paraziți din organism ca un tratament

The limbic lesion was removed surgically with 2 mm margin of normal tissue and diathermy of the adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.

Aşa cum am menţionat mai sus, cel t humaan papillomavirus adesea, infecţia cu HPV la bărbat este asimptomatică, tulpina cea mai frecvent implicată fiind 16 Seroprevalenţa anticorpilor specifici anti-HPV este mai scăzută la bărbaţi faţă de femei, la aceeaşi grupă de vârstă. Department of Ophthalmology, Grigore T. Explicaţiile acestui fapt pot fi: încărcătura virală mai scăzută, incidenţa şi parazitii 20 cm oficial infecţiei mai redusă, răspuns imun diminuat Printre factorii de risc de infectare, cei mai impor- tanţi sunt reprezentaţi de numărul partenerilor se- xuali, absenţa circumciziei, istoric de alte pathology of papillomavirus cu transmitere pathology of papillomavirus, istoric de fumat Spre deosebire de femei, care efectuează controale ginecologice în mod regulat, bărbaţii se adresează medicului numai când observă o modificare, în cazul vegetaţiilor genitale, unele dintre acestea t humaan papillomavirus fi foarte greu de observat de către pacient. Pe lângă protejarea împotriva infecţiei cu HPV, serotipu- rile cu risc oncogenic crescut, circumcizia reduce riscul infecţiei cu HIV inclusiv în cazul partenerelor Unele studii arată însă pathology of papillomavirus circumcizia diminuează transmite- rea tulpinilor HPV cu risc scăzut, neavând nici un efect asupra celor cu risc oncogenic crescut, probabil din cauza faptului că acestea sunt tulpini mult mai virulente Ca manifestări non-neoplazice, cele mai frecvente leziuni sunt vegetaţiile genitale, aşa-numitele veruci genitale. Ele sunt de mai multe tipuri: condiloma acu- minata, leziunile de tip plan, papulos, leziuni hiperke- ratozice.